NIH R15s: AREA and REAP Grants Astrid Haugen Health Specialist Genes, Environment, and Health Branch NIEHS Division of Extramural Research and Training National Institutes of Health U.S. Department of Health and Human Services Todays Topics Overview of R15 Program goals How to read R15 Funding Opportunity
Announcements (FOAs) Learn how R15 applications and projects differ from R01s Differences between AREA and REAP Strategies for success R15 Grant Mechanism Academic Research Enhancement Award (AREA) Undergraduate-Focused Institutions PAR-18-714 (no CT) and PAR-19-133 (CT) Research Enhancement Award Program (REAP)
Health Professional Schools and Graduate Schools Schools of medicine, dentistry, osteopathy, pharmacy, nursing, veterinary medicine, public health, optometry, allied health, chiropractic, naturopathy, and podiatry PAR-19-134 (no CT) and PAR-19-135 (CT) Program Goals Strengthen research environment of institutions that
have not been major recipients of NIH funding Support useful, interesting, publishable research Expose students to primary research Restructuring the R15: Intent and Rationale Returned to historical intent of AREA Support undergraduates access to research
opportunities and entry into biomedical research careers; however Continue to provide opportunity for faculty and students in heath professional schools to participate in a dedicated FOA via REAP For AREA and REAP: Maintain the key goals of the R15 program Allow for better reporting and evaluation E.g., tracking undergraduate students
Key Features Research Grant mechanism Up to $300,000 direct cost to be spent over 3 year-project period 12 page Research Strategy - Same criteria scoring as a R01, but different emphasis Grants are renewable Goals & Scope: Part 2, Section I, Funding Opportunity Description
... R15 vs. R01 Overall impact of R15 differs from R01 o o Smaller-scale research projects Limited scope o Due to resources (i.e., facilities, personnel)
Must describe opportunities for students o Absent from R01 Must describe how award will strengthen research environment of the institution o
Absent from R01 R15-Specific Eligibility Criteria: Part 2, Section III, Part 1 AREA and REAP are Mutually Exclusive Each program targets a different pool of faculty REAP: faculty at Health Professional Schools or Graduate Schools.
AREA: faculty at undergraduate-focused schools and colleges (not Health Professional or Graduate). Institution could have faculty eligible for each program Howeverindividual faculty cannot be eligible for both R15 programs AREA vs. REAP: Primary Appointment
R15 PI Eligibility Criteria: Primary Appointment Primary appointment at eligible institution REAP Heath Professional School or Graduate School faculty PAR-19-134 (no CT) and PAR-19-135 (CT) AREA Non-Health Professional School faculty PAR-18-714 (no CT) and PAR-19-133 (CT)
R15 PI Eligibility: Multiple PIs and Collaborators Multiple PI is OK, if all are FOA-eligible What about an ineligible collaborator? Yes! However. Be mindful of the intent and unique goals of the R15 Majority of research should be directed by PI at grantee institution Student profile & student inclusion are for applicant/eligible component
Collaborators add expertise, but be selective Other R15 PI Eligibility Criteria May not have an active NIH grant at time of award Can hold successive New or Renewal grants Can hold a subaward on someone elses NIH grant R15 is intended to be a PIs only NIH research
grant Organization Eligibility Criteria Organization must award at least a bachelors degree in biomedical sciences Total NIH support is no more than $6 million per year in 4 of the last 7 years Calculation parameters have changed Note instructions in specific FOA
Organization eligibility - AREA PAR-18-714 (no CT), PAR-19-133 (CT) All non-health professional components of the institution must have total NIH support no more than $6 million per year in 4 of the last 7 years Health professional schools not included in this calculation Undergraduate enrollment MUST be greater than graduate enrollment in the
non-health professional school https://grants.nih.gov/grants/funding/Determing-Organization-Funding-Levels-R15-Eligibility.pdf AREA Eligibility Organization eligibility - REAP PAR-19-134 (no CT), PAR-19-135 (CT) The entire institution (all components) must have total NIH support no more than $6 million per year in 4 of the last 7 years Includes support for non-health
professional and health professional schools Undergraduate enrollment level is not a factor for eligibility. https://grants.nih.gov/grants/funding/Determing-Organization-Funding-Levels-R15-Eligibility.pdf REAP Eligibility REAP Eligibility Scenario
REAP Eligibility Scenario II Non-Health Professional and Health professional Schools Painted Desert University Both AREA and REAP require a signed letter from the Provost or similar official verifying eligibility as specified in the
appropriate FOA Provost Letter Applications submitted without this letter will be withdrawn and returned without review. Is AREA or REAP right for me? Application instructions: Part 2, Section IV, Part 2
Before Writing Submission Read FOA carefully Write an abstract and sketch out some specific aimsone-pager Useful tool: use the Matchmaker tool of NIH Reporter (
https://projectreporter.nih.gov/reporter_ma tchmaker.cfm ) Check the NIH Institute mission statement page Talk to a Program Officer after emailing one-pager
The Art of Crafting an R15 Application Scientifically meaningful - Interesting questions & publishable data Feasible with - Resources (facility and personnel) - Effort - Students Appropriate scope Describe your environment
FOA has R15-specific instructions Other Project Information: Facilities and Other Resources Budget Biographical sketch Research Plan: Research Strategy Include a resource sharing plan! Research Strategy
Should touch each review criteria & program goals Preliminary data - Reviewers can and will evaluate submitted data Required to demonstrate appropriateness of project and group, including students Description of involvement & supervision of students How Students Will Be Involved?
Examples provided in both FOAs Perform & troubleshoot experiments Present at (lab) meetings & (campus) conferences (Help) design experiments
Collect & analyze data Draft articles Collaborative interactions Student Involvement Should Be Meaningful Number of students Quality of student involvement Not sufficient to say there will also be a couple undergrads (with an unspecified or insignificant role) Mention how students will be
recruited and student level (freshman senior) for AREA, or graduate students for REAP The Budget Can support a wide range of expenses - Student wages - Collaborator salaries (subawards) - Travel Keep R15 criteria in mind - Student involvement in primary research
- Improvement of R15-eligible institution - Impact on R15-eligible investigator Review criteria: Part 2, Section V, Part 1 R15 Application Review Where? a. Special Emphasis Panel for only R15 applications b. Chartered standing study sections with R01, R03, R21
Clustered for review Streamlined against R15 cluster; some institutes use percentile Assignment Request Form request special expertise and study section When to Apply Event Cycle I
Cycle II Cycle III February 25 June 25 October 25 AIDS Due Date
May 7 September 7 Jan 7 Scientific Merit Review June - July
October - November February - March October January May
December April July Standard Due date (non-AIDS) Advisory Council Round
Earliest Project Start Date After Submission Make sure your application is correctly assigned
Study section and Institute Check the meeting rosters and contact SRO, if needed Check the NIH Institute mission statement page Useful tool: use the Matchmaker tool of NIH Reporter Funding Trends https://report.nih.gov/success_rates/index.aspx
Success Rate Number of Applications and Awards Number of Applications Number of Awards Success Rate Funding Trends
After the Award Due annually, and must include: 2-page summary annual progress (not summary of history of grant) Section D Participants: list students who worked at least 1 person month per year (even if unpaid) - Each student must have Commons ID - Mentioning them in the research update is insufficient - Crucial for tracking students and determining
success of R15 program as a whole No Magic Formula Do not treat a successful [or not] application as an iron-clad template [of what not to do] - How many students - How many papers - What % of a collaborator - What % of special facilities - What amount or type of institutional support
What type of environment Read Summary Statement of review; call your Program Officer; resubmit Strategies for Success Build a vital research environment Understand the NIH extramural research program Know guidelines, deadlines, submission & correction process, and review criteria Create an environment for success Training
Protected time Set expectations Institutions Make a commitment to establish an environment in which research can succeed Start up packages for equipment and supplies Pilot grants, student research grants Credit for student involvement in research
Consider the importance of collaborative research Do not pressure PIs to submit applications that are not ready Applicants Be familiar with the FOA goals and review criteria - address each question in your application Pick a compelling research topic State the significance be articulate, avoid jargon, and write for the expert and non-expert
Propose a realistic scope Propose clear hypotheses Publish before you apply, if appropriate Rememberbefore you begin, consider Check institute strategic plan or mission Speak to institute Program Officer Applicants (cont.) Add collaborators as needed to bolster expertise Approach refers to methods but also to how the research plan will accomplish the objectives you
proposed Include students in a significant manner Remember, this is not a training grant Focus on hands-on research, not coursework Describe PIs role in research & supervision Parting thought dont be discouraged resubmit Links https://grants.nih.gov/grants/funding/r15.htm
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