Investigation of High Shear Granulation Particle Distribution

Investigation of High Shear Granulation Particle Distribution

Investigation of High Shear Granulation Particle Distribution Michael Lay Dr. Heather Emady Arizona Space Grant Symposium, April 14th 2018 Introduction: Particle Technology Characterization, handling, and processing of solids unlike fluids Behavior affected by: friction, density, porosity, structure Highly empirical field, conducive to research in fundamental phenomena Example equipment: hoppers, drums, granulators Introduction: High Shear Granulation

Process of adding liquid binder to powder to create larger granules Industries: pharmaceuticals, cosmetics, food production, detergent Studies highlight different regimes, further understanding of processing effects required. L/S Ratio Impeller Speed Drop Height / Impact Wet-massing time Experimental: Set-up

Objective: Maximize particles near 1 mm in diameter Water added to Microcrystalline Cellulose (MCC) Closely mimic single drop test, slow impellor, low liquid flowrate Four Liquid/solid ratios, two drop heights 5 minute dry mix, 10 mL/min water addition, 1 hour wetmassing 15 minute samples, sieve analysis Results: During Wetmassing 35.0% Normalized Weight Percentage 30.0% 25.0% 20.0%

15.0% 10.0% 5.0% 0.0% 0 15 100% L/S Ratio 110% L/S Ratio 120% L/S Ratio 130% L/S Ratio 30 45

Time (Minutes) 100% L/S Ratio High Drop 110% L/S Ratio High Drop 120% L/S Ratio High Drop 130% L/S Ratio High Drop Weight % of 1 mm particles mm particles formed over time Ideal L/S ratio near 110-120% L/S above 130% leads to much larger granules L/S below 100% lacks sufficient water to make large granules 60 Increasing drop height has greater

effect at lower L/S ratios Results: After 60 Minutes Normalizesd Weight Distribution 30.0% 20.0% 10.0% 100% L/S High 0.0% 0 130%

L/S High0.2 120% L/S Low 110% L/S High 0.4 100% L/S Low 0.6 Minimum130% Particle Size (mm) L/S Low 120% L/S High 0.8 110% L/S Low 1

Increased drop height lowered mean particle size for 100% and 110% Increased drop height had practically no effect on particle distribution for 120% and 130% for particles below 1 mm. L/S ratio of 120% had largest normalized percentage of particles near 1 mm. L/S below 100% lacks sufficient water to make large granules More than 50% of granules formed were larger than 1 mm for L/S ratios of 120% and 130% Conclusions: This Investigation An L/S ratio between 110% to 120% will maximize the normalized

percentage of 1 mm granules, but the distribution is broad Increasing drop height could narrow distribution since greater impact leads to great penetration by the liquid Drop height has a minimal effect on initial nucleation, and even less effect on final granulation formation Conclusions: Future Investigations Future goal: narrowing size distribution of granules Investigate size distributions of larger granules e.g. L/S ratio of 130% Alter impellor speed to verify literature and identify regime type Further characterize process equipment and solid properties to improve comprehension of underlying phenomena Ultimate Goal: create model that predicts size and distribution of formed granule

Acknowledgements NASA Space Grant ASU undergraduate research opportunities Dr. Heather Emady Manogna Adepu & Tianxiang Gao Desiree Crawl & Stephanee Germaine Thank you Questions?

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