Non servono gli antiaritmici? Prof Luigi Padeletti Universit di Firenze Heart Failure & Co. Caserta, 29-30 aprile 2011 Sommario degli studi sul trattamento farmacologico Studio CAST-I1 Pazienti 1498 Disegno dello studio
Encainide, flecainide/ placebo Risultato Sospeso per numero eccessivo di decessi nel braccio di studio CHF-STAT2 674 Amiodarone/Placebo SWORD3 546
d-sotalolo/Placebo ESVEM4 486 EPS-guidato/Holterguidato EMIAT5 1500 Amiodarone/Placebo Nessuna variazione rispetto alla mortalit globale CAMIAT6
1200 Amiodarone/Placebo Nessuna variazione rispetto alla mortalit globale 1 Echt, et al. N Engl J Med. 1991;324:7818. 2 Singh, et al. N Engl J Med. 1995;333:7782 (supported by Sanofi & Wyeth). 3 Waldo A.L. The Lancet; 1996;348:712. (supported by Bristol-Myers Squibb). Nessuna variazione rispetto alla mortalit globale Sospeso per numero eccessivo di decessi nel braccio di studio Mortalit elevata in ambedue
i bracci 4 Mason J.W. N Engl J Med. 1993;329(7):4528. (Supported by BristolMyers Squibb, Knoll Pharmaceutical, Boehringer-Ingelheim, Parke-Davis, and Ciba-Geigy). 5 Julian D.G. The Lancet. 1997;349:66774.(Supported by Sanofi) 6 Cairns J.A. The Lancet. 1997;349:67582. Implanted Standby Defibrillators In fact, the implanted defibrillator system represents an imperfect solution in search of a plausible and practical application. Bernard Lown and Paul Axelrod Circulation, Volume XLVI, October 1972 Secondary Prevention Trials:
Overall Death Arrhythmic Death 33% 28% 20% 20 Moss AJ. N Engl J Med. 1996;335:1933-40. Buxton AE. N Engl J Med. 1999;341:1882-90. 3 Moss AJ. N Engl J Med. 2002;346:877-83 4 Moss AJ. Presented before ACC 51st Annual Scientific Sessions, Late Breaking Clinical Trials, March 19, 2002. 5
The AVID Investigators. N Engl J Med. 1997;337:1576-83. 6 Kuck K. Circ. 2000;102:748-54. 7 Connolly S. Circ. 2000:101:1297-1302. 1 2 0 AVID 5 3 Years CASH 6 3 Years CIDS 7 3 Years Reason for treatment with AADs in ICD recipients
Prognostic importance of defibrillator shocks in patients with heart failure Benefits of adjuvant AADs in ICD patients Betabloccanti: Effetti sulla mortalit 26 trials > 24.000 pts Post-infarto BETABLOCCANTI PLACEBO RIDUZIONE
Mortalit Totale 934/12438 (7.5%) 1124/11860 (9.5%) - 21% Morte Improvvisa 288/8115 (3.5%) 401/7706 (5.2%) - 33%
YUSUF S. et al. Prog Cardiovas Dis, 1985; 17: 335-371 Clinical Trial summarizing Benefits of AADs Clinical Trial summarizing Benefits of AADs OPTIC Trial Side Effects of Beta-Blockers could be Beneficial Conclusions Adjunctive AAD therapy often is necessary in many patients with ICDs for control of recurrent ventricular tachyarrhythmias and prevention of ICD
shocks. Conclusions Given the scarsity of safe and effective AADs for this indication, the decision of when to start an AAD in the patient with an ICD must be individualized. Conclusions If AAD therapy is initiated, the potential for drug-related toxicities and device interactions must be recognized and anticipated.
No kidding, this is a matchless "success tool.") *** There's no such thing as a "dull meeting." (No kidding!) Every get together is an opportunity to press your agenda, directly or indirectly, to perform a small favor with the expectation...
Off-price retailers carry leftover goods, overruns, irregular merchandise sold at less than retail. Superstores are huge selling spaces, routinely purchased food and household items, plus services. Category killers carry a deep assortment in one category.
Wondrous sovreign of the sea, Jesus, Savior, pilot me. When at last I near the shore, and the fearful breakers roar 'twixt me and the peaceful rest, then, while leaning on thy breast, may I hear thee say to me,...
HoneyWell se colocó como el primer competidor durante la segunda generación de computadoras. Burroughs, Univac, NCR, CDC, HoneyWell, los más grandes competidores de IBM durante los 60s se conocieron como el grupo BUNCH (siglas). ... Su fiabilidad alcanza metas inimaginables...
Abstract by Mary Ellen Mogee. ... The history of the color wheel. Color gamuts. Application of the color wheel in painting. Review. We covered: How to mix neutrals (greys and browns) ... Understanding COLOR Theory III presentation by Pam Coulter
Chapter 10. Comparing feudal societies. ... They promoted Christian unity, served as examples of holy life, improved cultivation techniques, stressed productive work, and preserved the heritage of Greco-Roman culture. ... Signs of Strain.
Qiyas Examination Result. National Center for Assessment in Higher Education (Qiyas) Validate a given P.O.Box Address & Wasel . Saudi Post. GSB services available. Services. Provider. Student Record . Graduation Record - Composite Service. Student Admission - Composite Service.
Ready to download the document? Go ahead and hit continue!