Stnd: BI 4.d & 4c C-Notes: Cell Specialization & Sickle 11/12/13 Cell Anemia (Cells, Tissue, Organs) Objective: SWBAT recognize that cells in multi-cellular organisms differ in structure and
function. Why is Cell This process is needed because one Differentiation kind of cell cannot perform all the an important activities required for life. part of the All organisms are composed of cells. development Unicellular organisms consist of only 1
of a cell that performs all required function (job) to maintain life. multicellular Ex: Bacteria, Amoeba organism? Multicellular organisms are composed of more than 1 cell because they are more complex and cells are specialized/differentiated to perform certain functions. The body needs to supply food and
nutrients, transport materials, remove wastes and fight infection. Ex: Plants and animals What are Cells that differ in structure (size, Specialized shape) and function (the job they Cells? perform in the organism). Ex: bone cell, muscle cells, nerve cells, (Cell
skin cells, stem cells, blood cells, etc. Specialization) This is due to different patterns of gene expression rather than to differences of the genes themselves Advanced organisms (multi-cellular) have more specialized cells. An adult human is composed of approximately 100 trillion cells and has over 200 different types of specialized cells.
Examples of Cell Specialization 1. Neuron (nerve cell) - send and receive signals/info from one part of the body to another (Coordinates body actions.) - very long and thin Ex: Brain will send a signal through nerve cells to control a muscle and create movement Examples of Cell Specialization 2. Red Blood Cells - Picks up Oxygen from the lungs and carries it to body cells throughout the body.
- flattened round smooth disks so that they can easily flow through blood vessels Examples of Cell Specialization 3. Epithelial Cell cells that line the openings in the body and also cover flat surfaces (top layer). Ex: skin, pancreas, liver, lung and sinuses Examples of Cell Specialization 3. Muscle cells (3 types)
I. Cardiac Muscle cells Found ONLY in your heart II. Smooth Muscle cells Found in the digestive tract and in the walls of blood vessels III. Skeletal Muscle cells found attached to your bones and helps you move. It also helps protect your inner organs. Examples of Cell Specialization 3. Bone Cell
which are found within the bone tissue, are responsible for the make-up of the skeleton A collection of bone cells Will make bone tissue Examples of Cell Specialization 4. Stem Cell These are NON-SPECIALIZED cells in humans that can develop
(differentiate) into many different cell types. The daughter cells have the same DNA, but different genes may be turned on or off. Stem Cell Research
Examples of Cell Specialization 5. Xylem and Phloem Cell (Root Cells) To absorb and transport materials (water/nutrients) throughout plants from the soil. What is the Level of Organization of an Organism? Cell Organization:
Cells: basic unit of structure and function of all living things. Ex: white blood cell, muscle cell Tissue: A group of similar cells performing the same function. Example: muscle tissue, blood tissue Organ: A group of specialized tissues performing one main function. Ex: stomach, kidney Organ System: A group of organs that carry on one of the major body functions. Ex: digestive system, nervous system
Organism: An organism is made up of organ systems that perform its life functions. Ex: plants and animals Levels of Organization Tissues in the Arm Cell Specialization External Cues
Internal Gene Regulation Cell Specialization Stem Cells What is Sickle Cell Anemia?
It is a disorder/ disease caused by a single mutation (missense point mutation) in the DNA code for the protein hemoglobin in red blood cell that gives the production of red blood cells a sickle shape. In Sickle cell anemia , the DNA code contains a substitution of an adenine to a thymine, which causes the amino acid to change Valine Acid for Glutamic Acid (one amino acid change). Normal RBCs contain hemoglobin that is 100% full of oxygen.
Sickle Cell hemoglobin contains only about 70% oxygen and the shape can cause blockages in the blood vessels, preventing the RBCs from reaching body cells with the oxygen they are carrying. This decrease in the ability to deliver oxygen is a reason why sickle cell anemia is a serious health threat. Normal and Sickled Red Blood Cells in Blood Vessels Figure B shows abnormal, sickled red blood cells clumping and blocking the blood flow in a blood vessel.
The inset image shows a cross-section of a sickled red blood cell with abnormal strands of hemoglobin. Figure A shows normal red blood cells flowing freely in a blood vessel. The inset image shows a cross-section of a normal red blood cell with normal hemoglobin. Source from http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_WhatIs.html and how does it affect them? Blood Cells They die
Blood Flow Not so good Body Parts/Organs Yeah, theyre affected Immune System As open as Detroits offensive line Which one has sickle cells?
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