transports substances and maintains homeostasis in the body Hematophobia = fear of blood BLOOD AND BLOOD CELLS Blood
is a type of CONNECTIVE TISSUE It has two basic components: CELLS (rbc, wbc, platelets) = 45% Plasma (water, proteins, amino acids..etc) = 55%
Hematocrit - volume of blood cells in a sample, should be 45%. The remaining fluid is plasma
(55%). To determine the percentages, blood is placed in a centrifuge Three Types of Blood Cells Red blood cells (erythrocytes) White blood cells
(leukocytes) Platelets (thrombocytes) Biconcave discs 5 million per cubic millimeter
Lack nuclei HEMATOPOEISIS formation of blood cells (bone marrow) Liver & Spleen - phagocytosis EPO, OR ERYTHROPOIETIN (PRONOUNCED, AHRITH-RO-POY-TIN), IS A HORMONE PRODUCED BY THE LIVER AND KIDNEYS.
In the first part of a two-night interview broadcast, disgraced cyclist Lance Armstrong admitted to Oprah Winfrey that he
took banned substances, including EPO, during all seven of his Tour de France victories. ERYTHROPOIETIN
Erythropoietin (EPO) is a hormone produced by the kidney that promotes the formation of red blood cells by the bone marrow. The resultant rise in red cells increases the oxygen-carrying capacity of the blood. 90% erythropoietin is produced by the kidneys
10% erythropoietin is produced by the liver Normal levels of erythropoietin range from 4 up to 24 mU/ml (milliunits per milliliter). MAIN FUNCTIONS OF RED BLOOD CELLS Transports
oxygen, picks up carbon dioxide HEMOGLOBIN molecule that combines with O2 IRON is critical to synthesize hemoglobin
OXYGEN LEVELS Oxyhemoglobin = plenty of oxygen; bright red Deoxyhemoglobin = low in O2, bluish red The blood on the left is oxygenated, the right is deoxygenated blood (from a vein)
OXYGENATED DEOXYGENATED ELEMENTS CRITICAL TO RBC PRODUCTION
Folic Acid Vitamin B12 Iron Too few RBC = anemia WHITE BLOOD CELLS (LEUKOCYTES)
General function is to protect the body against disease There are FIVE different kinds of WBCs Granulocytes (granular cytoplasm) Neutrophils, Eosinophils, Basophils Agranulocytes (lacking granular cytoplasm)
Monocytes, Lymphocytes NEUTROPHIL (NUCLEUS HAS SEVERAL LOBES) Active phagocytes 60% of WBC
Present in the pus of wounds BASOPHIL Produces Heparin and Histamines Important in Inflammatory Reaction 1% WBC
Larger cell, horseshoe-shaped nucleus Become macrophages LYMPHOCYTES Nucleus is dark and takes up almost whole
cell; almost no cytoplasm seen Defense against invaders Yield Antibodies 30% WBC Left: Lymphoctye | Right: Neutrophil
ANIMATION: IMMUNE SYSTEM RESPONSE PLATELETS (THROMBOCYTES) Blood clots and vessel repair ERYTHROPOIESIS DESCRIBES THE
PRODUCTION OF RED BLOOD CELLS The red bone marrow of essentially all bones produces RBCs from birth to about five years of age. Between the ages of 5 to 20, the long bones slowly lose their ability to produce RBCs. Above age 20, most RBCs are produced primarily in the marrow of the vertebrae, the
sternum, the ribs, and the pelvis. ERYTHROPOIESIS DESCRIBES THE PRODUCTION OF RED BLOOD CELLS LIFE CYCLE OF THE RED BLOOD CELL -120 DAYS
1) Kidneys respond to a lower than normal oxygen concentration in the blood by releasing the hormone erythropoietin. 2) Erythropoietin travels to the red bone marrow and stimulates an increase in the production of red blood cells (RBCs). 3) The red bone marrow manufactures RBCs
from stem cells that live inside the marrow. 4) RBCs squeeze through blood vessel membranes to enter the circulation. 5) The heart and lungs work to supply continuous movement and oxygenation of RBCs. 6) Damaged or old RBCs are destroyed primarily by the spleen
PLASMA PROTEINS Albumins blood pressure Globulins (alpha, beta, gamma) transport lipids and antibodies for immunity
Fibrinogen important for blood clotting MAJOR EVENT IN BLOOD CLOTTING = Fibrinogen converted to FIBRIN PLASMA The liquid portion of blood is 92% water Also contains nutrients, gases, vitamins (etc)
and plasma proteins This machine removes the plasma from the blood and returns the RBCs to the donor. HEMOSTASIS The process of stopping bleeding
Involves the coagulation and clotting of the blood to seal the site of damage THREE EVENTS IN HEMOSTASIS 1. Blood Vessel Spasm
Seratonin = vasoconstrictor 2. Platelet plug formation 3. Blood coagulation - conversion of fibrinogen to fibrin *Thrombin is an enzyme that causes the conversion
HEMOSTASIS COAGULATION THE THICKENING OF BLOOD TO FORM A CLOT (HEMATOMA) THROMBUS
blood clot (abnormal) EMBOLUS when the clot moves to another place.
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